MCM7

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.^[5]

MCM7
Identifiers
Aliases	MCM7, CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104, minichromosome maintenance complex component 7
External IDs	OMIM: 600592; MGI: 1298398; HomoloGene: 4323; GeneCards: MCM7; OMA:MCM7 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 100,092,728 bp[1] End 100,101,940 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 138,162,845 bp[2] End 138,170,684 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone mucosa of transverse colon lymph node C1 segment right testis appendix left testis granulocyte bone marrow Top expressed in ventricular zone epiblast bone marrow thymus genital tubercle tail of embryo ganglionic eminence embryo embryo yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding helicase activity DNA helicase activity single-stranded DNA binding protein binding hydrolase activity ATP binding DNA binding DNA replication origin binding single-stranded 3'-5' DNA helicase activity Cellular component membrane nucleoplasm chromatin MCM complex cytosol nucleus nucleolus Biological process cellular response to organic substance G1 phase cellular response to xenobiotic stimulus regulation of phosphorylation cellular response to DNA damage stimulus cellular response to epidermal growth factor stimulus DNA replication initiation cell cycle cell population proliferation DNA unwinding involved in DNA replication DNA replication G1/S transition of mitotic cell cycle double-strand break repair via break-induced replication pre-replicative complex assembly involved in nuclear cell cycle DNA replication DNA strand elongation involved in DNA replication Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4176 17220 Ensembl ENSG00000166508 ENSMUSG00000029730 UniProt P33993 Q61881 RefSeq (mRNA) NM_001278595 NM_005916 NM_182776 NM_008568 NM_001356576 NM_001356577 RefSeq (protein) NP_001265524 NP_005907 NP_877577 NP_032594 NP_001343505 NP_001343506 Location (UCSC) Chr 7: 100.09 – 100.1 Mb Chr 5: 138.16 – 138.17 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[6]

Interactions

MCM7 has been shown to interact with:

• CDC45-related protein^[7][8]
• CDC6,^[7][9]
• Cell division cycle 7-related protein kinase,^[7]
• DBF4,^[7]
• MCM2,^{[7][10][11][12][13]}
• MCM3,^{[7][9][10][14]}
• MCM4,^{[10][11][12][15]}
• MCM5,^[7][10][16]
• MCM6,^{[7][10][11][12]}
• MNAT1,^[17]
• ORC1L,^[7]
• ORC2L,^[7]
• ORC3L,^[7]
• ORC5L,^[7]
• Replication protein A1,^[7]
• Retinoblastoma protein,^[18] and
• UBE3A.^[19]

See also

• Mini Chromosome Maintenance