MCF2

Proto-oncogene DBL is a protein that in humans is encoded by the MCF2 gene.^[4][5][6]

MCF2
Identifiers
Aliases	MCF2, ARHGEF21, DBL, MCF.2 cell line derived transforming sequence
External IDs	OMIM: 311030; MGI: 96932; HomoloGene: 3917; GeneCards: MCF2; OMA:MCF2 - orthologs
Gene location (Mouse) Chr. X chromosome (mouse)[1] Band X A6|X 33.5 cM Start 59,101,316 bp[1] End 59,224,449 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula endothelial cell Brodmann area 23 hypothalamus Brodmann area 9 prefrontal cortex substantia nigra pons middle temporal gyrus nucleus accumbens Top expressed in lumbar subsegment of spinal cord facial motor nucleus anterior horn of spinal cord epiblast embryo zygote spermatocyte embryo substantia nigra lateral geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding guanyl-nucleotide exchange factor activity Cellular component cytoplasm cytosol cytoskeleton membrane Biological process regulation of Rho protein signal transduction intracellular signal transduction regulation of small GTPase mediated signal transduction positive regulation of apoptotic process G protein-coupled receptor signaling pathway negative regulation of axonogenesis dendrite development cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4168 109904 Ensembl n/a ENSMUSG00000031139 UniProt P10911 n/a RefSeq (mRNA) NM_001099855 NM_001171876 NM_001171877 NM_001171878 NM_001171879 NM_005369 NM_001289730 NM_001289731 NM_133197 NM_001358998 NM_001358999 NM_001359000 NM_001359001 RefSeq (protein) NP_001093325 NP_001165347 NP_001165348 NP_001165349 NP_001165350 NP_005360 n/a Location (UCSC) n/a Chr X: 59.1 – 59.22 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

The commonly used name DBL is derived from “diffuse B-cell lymphoma”, the cancer type where this gene was first identified as an oncogene,^[7] while the name MCF2 name derives from “MCF.2 cell line-derived transforming sequence”.^[8]

DBL is the founding member of a large family of guanine nucleotide exchange factors that share a common DBL-homology (DH) domain), so DBL is also named as a member of this RhoGEF family as ARHGEF21. DH domains function to activate small GTPases of the Rho family by facilitating release of GDP from an inactive Rho GTPase and binding of GTP to activate it. In particular, DBL activates the Rho family member Cdc42.^[9]

Gene recombinations that result in the loss of N-terminal regions produce MCF2 variants with oncogenic activity.[supplied by OMIM]^[6]