MDFI

MyoD family inhibitor is a protein that in humans is encoded by the MDFI gene.^[5][6][7]

MDFI
Identifiers
Aliases	MDFI, MyoD family inhibitor, I-MF, I-mfa
External IDs	OMIM: 604971; MGI: 107687; HomoloGene: 21150; GeneCards: MDFI; OMA:MDFI - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 41,636,882 bp[1] End 41,654,244 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 C|17 23.99 cM Start 48,126,253 bp[2] End 48,145,616 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone mucosa of pharynx ectocervix minor salivary glands body of tongue olfactory zone of nasal mucosa gallbladder canal of the cervix vagina Top expressed in yolk sac basilar part of occipital bone genital tubercle external carotid artery internal carotid artery humerus Meckel's cartilage lip esophagus maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding transcription factor binding Cellular component cytoplasm nucleus Biological process cytoplasmic sequestering of transcription factor embryonic skeletal system morphogenesis multicellular organism development trophoblast giant cell differentiation cell differentiation negative regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II dorsal/ventral axis specification negative regulation of Wnt signaling pathway negative regulation of DNA binding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4188 17240 Ensembl ENSG00000112559 ENSMUSG00000032717 UniProt Q99750 P70331 RefSeq (mRNA) NM_001300804 NM_001300805 NM_001300806 NM_005586 NM_001109973 NM_001276390 NM_001276391 NM_010783 RefSeq (protein) NP_001287733 NP_001287734 NP_001287735 NP_005577 NP_001103443 NP_001263319 NP_001263320 NP_034913 Location (UCSC) Chr 6: 41.64 – 41.65 Mb Chr 17: 48.13 – 48.15 Mb PubMed search [3] [4]
Wikidata
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Function

This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures.^[7]

Interactions

MDFI has been shown to interact with:

• C9orf86,^[8]
• GNAI2,^[8]
• MyoD,^[9]
• Myogenin,^[9] and
• SIX1.^[8]