MDM4

Protein Mdm4 is a protein that in humans is encoded by the MDM4 gene.^[5][6]

MDM4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CR8, 2VJE, 2VJF, 2VYR, 3DAB, 3EQY, 3FDO, 3FE7, 3FEA, 3JZO, 3JZP, 3JZQ, 3LBJ, 3MQR, 3U15, 4RXZ, 2MWY, 2N06, 2N0W, 2N14, 2N0U
Identifiers
Aliases	MDM4, HDMX, MDMX, MRP1, p53 regulator, MDM4 regulator of p53, BMFS6
External IDs	OMIM: 602704; MGI: 107934; HomoloGene: 1794; GeneCards: MDM4; OMA:MDM4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 204,516,379 bp[1] End 204,558,120 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 E4|1 57.75 cM Start 132,887,222 bp[2] End 132,958,299 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple oocyte epithelium of colon trabecular bone skin of thigh pylorus Achilles tendon sural nerve cardia pericardium Top expressed in secondary oocyte primary oocyte zygote genital tubercle saccule tail of embryo granulocyte neural layer of retina otic placode spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme binding protein binding metal ion binding ubiquitin protein ligase activity zinc ion binding Cellular component nucleus nucleoplasm Biological process G0 to G1 transition DNA damage response, signal transduction by p53 class mediator protein stabilization cell population proliferation negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II cellular response to hypoxia negative regulation of protein catabolic process negative regulation of cell population proliferation protein ubiquitination DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest regulation of signal transduction by p53 class mediator protein deubiquitination protein-containing complex assembly heart valve development atrioventricular valve morphogenesis endocardial cushion morphogenesis ventricular septum development atrial septum development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4194 17248 Ensembl ENSG00000198625 ENSMUSG00000054387 UniProt O15151 Q5T0Y2 O35618 RefSeq (mRNA) NM_001204171 NM_001204172 NM_001278516 NM_001278517 NM_001278518 NM_001278519 NM_002393 NM_008575 NM_001302801 NM_001302802 NM_001302803 NM_001302804 RefSeq (protein) NP_001191100 NP_001191101 NP_001265445 NP_001265446 NP_001265447 NP_001265448 NP_002384 NP_001289730 NP_001289731 NP_001289732 NP_001289733 NP_032601 Location (UCSC) Chr 1: 204.52 – 204.56 Mb Chr 1: 132.89 – 132.96 Mb PubMed search [3] [4]
Wikidata
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Function

The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2^[6]

Interactions

MDM4 has been shown to interact with E2F1,^[7] Mdm2^{[8][9][10][11]} and P53.^[5][10]