MDMAR

3',4'-Methylenedioxy-4-methylaminorex (MDMAR) is a recreational designer drug from the substituted aminorex family, with monoamine-releasing effects.^[1][2][3] It is a potent serotonin–norepinephrine–dopamine releasing agent (SNDRA).^[1]

Monoamine release of MDMAR and related agents (EC₅₀Tooltip Half maximal effective concentration, nM)

Compound	NETooltip Norepinephrine	DATooltip Dopamine	5-HTTooltip Serotonin	Ref
Phenethylamine	10.9	39.5	>10,000	[4][5][6]
Dextroamphetamine	6.6–10.2	5.8–24.8	698–1,765	[7][8][6][9]
Dextromethamphetamine	12.3–14.3	8.5–40.4	736–1,292	[7][10][6][9]
Aminorex	15.1–26.4	9.1–49.4	193–414	[7][11][6][3][9]
cis-4-MAR	4.8	1.7	53.2	[3][11]
cis-4,4'-DMAR	11.8–31.6	8.6–24.4	17.7–59.9	[11][1][3]
trans-4,4'-DMAR	31.6	24.4	59.9	[1][3]
cis-MDMAR	14.8	10.2	43.9	[1]
trans-MDMAR	38.9	36.2	73.4	[1]
Notes: The smaller the value, the more strongly the drug releases the neurotransmitter. The assays were done in rat brain synaptosomes and human potencies may be different. See also Monoamine releasing agent § Activity profiles for a larger table with more compounds. Refs: [12][13]

3',4'-Methylenedioxy-4-methylaminorex

Clinical data
Other names	3',4'-Methylenedioxy-4-methylaminorex
Identifiers
IUPAC name 5-(1,3-benzodioxol-5-yl)-4-methyl-4,5-dihydro-1,3-oxazol-2-amine
CAS Number	1445573-16-9
PubChem CID	163190697
UNII	S2DX832LDF
CompTox Dashboard (EPA)	DTXSID201336901
Chemical and physical data
Formula	C11H12N2O3
Molar mass	220.228 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1C(OC(=N1)N)C2=CC3=C(C=C2)OCO3
InChI InChI=1S/C11H12N2O3/c1-6-10(16-11(12)13-6)7-2-3-8-9(4-7)15-5-14-8/h2-4,6,10H,5H2,1H3,(H2,12,13) Key:JFKNBDXNCLMRPL-UHFFFAOYSA-N

See also

• 2C-B-aminorex
• 4B-MAR
• 4C-MAR
• 4,4'-DMAR
• 4'-Fluoro-4-methylaminorex
• 5-MAPB
• MDMA
• Methylenedioxyphenmetrazine
• List of aminorex analogues