MED16

Mediator of RNA polymerase II transcription subunit 16 is an enzyme that in humans is encoded by the MED16 gene.^[5][6][7]

MED16
Identifiers
Aliases	MED16, DRIP92, THRAP5, TRAP95, mediator complex subunit 16
External IDs	OMIM: 604062; MGI: 2158394; HomoloGene: 64602; GeneCards: MED16; OMA:MED16 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 867,630 bp[1] End 893,218 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 79,730,542 bp[2] End 79,744,757 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right uterine tube right lobe of liver gastric mucosa canal of the cervix apex of heart gonad granulocyte anterior pituitary muscle of thigh Top expressed in seminiferous tubule internal carotid artery external carotid artery spermatocyte Rostral migratory stream epithelium of stomach dentate gyrus of hippocampal formation granule cell tibiofemoral joint molar extraocular muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function vitamin D receptor binding transcription coregulator activity thyroid hormone receptor binding catalytic activity transcription coactivator activity protein binding signaling receptor activity Cellular component nucleoplasm nucleus mediator complex membrane Biological process transcription, DNA-templated regulation of transcription by RNA polymerase II androgen receptor signaling pathway intracellular steroid hormone receptor signaling pathway positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter positive regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10025 216154 Ensembl ENSG00000282092 ENSG00000175221 ENSMUSG00000013833 UniProt Q9Y2X0 Q6PGF3 RefSeq (mRNA) NM_005481 NM_001163276 NM_198107 NM_001359629 RefSeq (protein) NP_005472 XP_006513550.1 XP_006513551.1 Location (UCSC) Chr 19: 0.87 – 0.89 Mb Chr 10: 79.73 – 79.74 Mb PubMed search [3] [4]
Wikidata
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Interactions

MED16 has been shown to interact with Thyroid hormone receptor alpha,^[6] Estrogen receptor alpha^[8] and Cyclin-dependent kinase 8.^[6][8]