MED22

Mediator of RNA polymerase II transcription subunit 22 is an enzyme that in humans is encoded by the MED22 gene.^[5][6][7]

MED22
Identifiers
Aliases	MED22, MED24, SURF5, surf-5, mediator complex subunit 22, SRB6
External IDs	OMIM: 185641; MGI: 98446; HomoloGene: 4913; GeneCards: MED22; OMA:MED22 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.2 Start 133,338,312 bp[1] End 133,348,131 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A3|2 19.09 cM Start 26,795,274 bp[2] End 26,800,689 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood sural nerve muscle layer of sigmoid colon right coronary artery body of uterus gastric mucosa prefrontal cortex apex of heart left uterine tube Top expressed in ventricular zone spermatocyte Rostral migratory stream ganglionic eminence primary oocyte medial ganglionic eminence secondary oocyte zygote lip lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coregulator activity protein binding Cellular component cytoplasm mediator complex nucleus Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6837 20933 Ensembl ENSG00000281022 ENSG00000148297 ENSMUSG00000015776 UniProt Q15528 Q5T8T8 Q62276 RefSeq (mRNA) NM_181491 NM_006752 NM_133640 NM_001033908 NM_011513 NM_001378786 NM_001378787 NM_001378788 RefSeq (protein) NP_598395 NP_852468 NP_001029080 NP_035643 NP_001365715 NP_001365716 NP_001365717 Location (UCSC) Chr 9: 133.34 – 133.35 Mb Chr 2: 26.8 – 26.8 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is located in the surfeit gene cluster, a group of very tightly linked housekeeping genes that do not share sequence similarity. The gene is oriented in a head-to-head fashion with RPL7A (SURF3) and the two genes share a bidirectional promoter. The encoded proteins are localized to the cytoplasm. Two alternative transcript variants encoding different isoforms have been identified for this gene.^[7]

Interactions

MED22 has been shown to interact with MED30.^[8]