MED28

Mediator of RNA polymerase II transcription subunit 28 is an enzyme that in humans is encoded by the MED28 gene.^[5][6][7] It forms part of the Mediator complex.

MED28
Identifiers
Aliases	MED28, 1500003D12Rik, EG1, magicin, mediator complex subunit 28
External IDs	OMIM: 610311; MGI: 1914249; HomoloGene: 11873; GeneCards: MED28; OMA:MED28 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.32 Start 17,614,641 bp[1] End 17,634,105 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B3 Start 45,677,571 bp[2] End 45,686,618 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid buccal mucosa cell ventricular zone monocyte palpebral conjunctiva embryo ganglionic eminence thymus gastrocnemius muscle cartilage tissue Top expressed in primary oocyte medial ganglionic eminence spermatid right kidney zygote proximal tubule spermatocyte endocardial cushion seminiferous tubule arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding Cellular component cytoplasm mediator complex cytoskeleton membrane nucleus cortical actin cytoskeleton nucleoplasm Biological process stem cell population maintenance regulation of transcription, DNA-templated negative regulation of smooth muscle cell differentiation transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80306 66999 Ensembl ENSG00000118579 ENSMUSG00000015804 UniProt Q9H204 Q920D3 RefSeq (mRNA) NM_025205 NM_025895 RefSeq (protein) NP_079481 NP_080171 Location (UCSC) Chr 4: 17.61 – 17.63 Mb Chr 5: 45.68 – 45.69 Mb PubMed search [3] [4]
Wikidata
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Med28
Identifiers
Symbol	Med28
Pfam	PF11594
InterPro	IPR021640
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Function

Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress smooth muscle cell differentiation. Thus, mammalian Mediator subunit Med28 functions as a repressor of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth muscle cell growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle tumours.^[8]

Interactions

MED28 has been shown to interact with Merlin,^[6] Grb2^[6] and MED26.^[9]

See also

• Mediator complex