MED7

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Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene.^[5][6]

MED7
Identifiers
Aliases	MED7, ARC34, CRSP33, CRSP9, mediator complex subunit 7
External IDs	OMIM: 605045; MGI: 1913463; HomoloGene: 3153; GeneCards: MED7; OMA:MED7 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.3 Start 157,137,424 bp[1] End 157,159,019 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.1 Start 46,327,752 bp[2] End 46,333,548 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Epithelium of choroid plexus sperm germinal epithelium endothelial cell Achilles tendon palpebral conjunctiva kidney tubule corpus epididymis testicle gonad Top expressed in medullary collecting duct secondary oocyte renal corpuscle lens primary oocyte atrioventricular valve seminiferous tubule tail of embryo medial ganglionic eminence maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity transcription coregulator activity protein binding ubiquitin protein ligase activity Cellular component mediator complex nucleus transcription regulator complex nucleoplasm ubiquitin ligase complex nuclear body Biological process regulation of transcription by RNA polymerase II stem cell population maintenance transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated protein ubiquitination transcription, DNA-templated positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9443 66213 Ensembl ENSG00000155868 ENSMUSG00000020397 UniProt O43513 Q9CZB6 RefSeq (mRNA) NM_004270 NM_001100816 NM_001104530 NM_001104556 NM_001104557 NM_025426 RefSeq (protein) NP_001094286 NP_004261 NP_001098000 NP_001098026 NP_001098027 NP_079702 Location (UCSC) Chr 5: 157.14 – 157.16 Mb Chr 11: 46.33 – 46.33 Mb PubMed search [3] [4]
Wikidata
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The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.^[6]