MED8

Mediator of RNA polymerase II transcription subunit 8 is an enzyme that in humans is encoded by the MED8 gene.^[5][6][7]

MED8
Identifiers
Aliases	MED8, ARC32, mediator complex subunit 8
External IDs	OMIM: 607956; MGI: 1915269; HomoloGene: 10560; GeneCards: MED8; OMA:MED8 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 43,383,917 bp[1] End 43,389,808 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.1|4 Start 118,266,534 bp[2] End 118,272,979 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte stromal cell of endometrium anterior pituitary mucosa of esophagus mucosa of transverse colon skin of leg body of pancreas skin of abdomen body of stomach Top expressed in ectoderm otic vesicle otic placode saccule yolk sac abdominal wall medial ganglionic eminence fetal liver hematopoietic progenitor cell endocardial cushion epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coregulator activity protein binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component mediator complex nucleus nucleoplasm core mediator complex Biological process regulation of transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated protein ubiquitination transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 112950 80509 Ensembl ENSG00000159479 ENSMUSG00000006392 UniProt Q96G25 Q9D7W5 RefSeq (mRNA) NM_201542 NM_001001653 NM_052877 NM_001290688 NM_020000 NM_173719 RefSeq (protein) NP_001001653 NP_443109 NP_963836 NP_001277617 NP_064384 NP_776067 Location (UCSC) Chr 1: 43.38 – 43.39 Mb Chr 4: 118.27 – 118.27 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein that is one of more than 20 subunits of the mediator complex, first identified in S. cerevisiae, that is required for activation of transcription. The product of this gene also interacts with elongins B and C, and CUL2 and RBX1, to reconstitute a ubiquitin ligase. Five alternative transcripts encoding four isoforms have been described.^[7]

Interactions

MED8 has been shown to interact with MED26.^[8]