MEGF10

Multiple EGF-like-domains 10 is a protein that in humans is encoded by the MEGF10 gene.^[5]

MEGF10
Identifiers
Aliases	MEGF10, EMARDD, multiple EGF like domains 10, SR-F3
External IDs	OMIM: 612453; MGI: 2685177; HomoloGene: 23771; GeneCards: MEGF10; OMA:MEGF10 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q23.2 Start 127,290,796 bp[1] End 127,465,737 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 D3 Start 57,266,162 bp[2] End 57,430,539 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum ventricular zone external globus pallidus inferior ganglion of vagus nerve endothelial cell subthalamic nucleus internal globus pallidus Brodmann area 23 tibia pars reticulata Top expressed in otolith organ utricle trigeminal ganglion substantia nigra ventricular zone globus pallidus deep cerebellar nuclei lobe of cerebellum cerebellar vermis vestibular sensory epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function complement component C1q complex binding scavenger receptor activity Notch binding Cellular component integral component of membrane cell projection membrane phagocytic cup plasma membrane Biological process skeletal muscle satellite cell differentiation regulation of skeletal muscle tissue development homotypic cell-cell adhesion recognition of apoptotic cell muscle organ development skeletal muscle satellite cell activation cell adhesion muscle cell development regulation of muscle cell differentiation skeletal muscle satellite cell proliferation phagocytosis receptor-mediated endocytosis muscle cell proliferation engulfment of apoptotic cell myoblast migration apoptotic process involved in development apoptotic cell clearance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84466 70417 Ensembl ENSG00000145794 ENSMUSG00000024593 UniProt Q96KG7 Q6DIB5 RefSeq (mRNA) NM_001256545 NM_001308119 NM_001308121 NM_032446 NM_001001979 RefSeq (protein) NP_001243474 NP_001295048 NP_001295050 NP_115822 NP_001001979 Location (UCSC) Chr 5: 127.29 – 127.47 Mb Chr 18: 57.27 – 57.43 Mb PubMed search [3] [4]
Wikidata
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MEGF10 is a regulator of satellite cell myogenesis and interacts with Notch1 in myoblasts.^[6] It has been shown to be the cause of early-onset myopathy, areflexia, respiratory distress and dysphagia.^[7]

MEGF10 and MEGF11, have critical roles in the formation of mosaics by two retinal interneuron subtypes, starburst amacrine cells and horizontal cells in mice. These cells are less likely to be near neighbours of the same subtype than would occur by chance, resulting in 'exclusion zones' that separate them. Mosaic arrangements provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements.^[8]