MEIS1

Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene.^[5][6]

MEIS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XRS
Identifiers
Aliases	MEIS1, Meis homeobox 1
External IDs	OMIM: 601739; MGI: 104717; HomoloGene: 135741; GeneCards: MEIS1; OMA:MEIS1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p14 Start 66,433,452 bp[1] End 66,573,869 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A3.1|11 11.11 cM Start 18,829,817 bp[2] End 18,968,985 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube gastric mucosa body of uterus canal of the cervix left uterine tube stromal cell of endometrium ectocervix palpebral conjunctiva right adrenal gland myometrium Top expressed in vestibular membrane of cochlear duct lacrimal gland parotid gland external carotid artery efferent ductule vas deferens superior cervical ganglion conjunctival fornix urethra abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific chromatin binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding protein heterodimerization activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding Cellular component transcription regulator complex nucleus Biological process megakaryocyte development regulation of transcription, DNA-templated blood vessel morphogenesis negative regulation of neuron differentiation locomotory behavior transcription by RNA polymerase II transcription, DNA-templated multicellular organism development lens morphogenesis in camera-type eye angiogenesis definitive hemopoiesis negative regulation of myeloid cell differentiation positive regulation of transcription by RNA polymerase II negative regulation of cardiac muscle cell proliferation hemopoiesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4211 17268 Ensembl ENSG00000143995 ENSMUSG00000020160 UniProt O00470 Q60954 RefSeq (mRNA) NM_002398 NM_001193271 NM_010789 RefSeq (protein) NP_002389 NP_001180200 NP_034919 Location (UCSC) Chr 2: 66.43 – 66.57 Mb Chr 11: 18.83 – 18.97 Mb PubMed search [3] [4]
Wikidata
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Function

Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.^[6]

Interactions

MEIS1 has been shown to interact with PBX1^[7][8][9] and HOXA9.^[7][10]