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MAP2K2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

MAP2K2
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Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene.[5] It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2.[6]

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Function

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK3/ERK1.

The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases.

The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.[7]

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Interactions

MAP2K2 has been shown to interact with MAPK3[8][9][10] and ARAF.[11]

References

Further reading

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