MAPK3

Main article: Extracellular signal-regulated kinases

Mitogen-activated protein kinase 3, also known as p44MAPK and ERK1,^[5] is an enzyme that in humans is encoded by the MAPK3 gene.^[6]

MAPK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ZOQ, 4QTB
Identifiers
Aliases	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK, mitogen-activated protein kinase 3
External IDs	OMIM: 601795; MGI: 1346859; HomoloGene: 55682; GeneCards: MAPK3; OMA:MAPK3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 30,114,105 bp[1] End 30,123,506 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F3|7 69.25 cM Start 126,358,773 bp[2] End 126,364,991 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe mucosa of transverse colon amygdala cingulate gyrus anterior cingulate cortex gastric mucosa nucleus accumbens ectocervix rectum C1 segment Top expressed in granulocyte dentate gyrus of hippocampal formation granule cell yolk sac pyloric antrum lip entorhinal cortex large intestine colon epithelium of stomach duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatase binding ATP binding protein kinase activity MAP kinase activity transferase activity phosphotyrosine residue binding scaffold protein binding protein binding nucleotide binding kinase activity protein serine/threonine kinase activity MAP kinase kinase activity identical protein binding Cellular component cytosol nuclear envelope focal adhesion mitochondrion cytoskeleton nucleus late endosome Golgi apparatus early endosome pseudopodium nucleoplasm cytoplasm plasma membrane caveola membrane protein-containing complex Biological process caveolin-mediated endocytosis positive regulation of protein phosphorylation positive regulation of telomere capping response to exogenous dsRNA cardiac neural crest cell development involved in heart development positive regulation of xenophagy positive regulation of translation cellular response to DNA damage stimulus platelet activation Fc-epsilon receptor signaling pathway protein phosphorylation cellular response to mechanical stimulus face development positive regulation of histone modification regulation of DNA-binding transcription factor activity DNA damage induced protein phosphorylation positive regulation of ERK1 and ERK2 cascade animal organ morphogenesis cell cycle apoptotic process Fc-gamma receptor signaling pathway involved in phagocytosis thymus development ERK1 and ERK2 cascade negative regulation of apolipoprotein binding transcription, DNA-templated cartilage development viral process response to toxic substance regulation of stress-activated MAPK cascade phosphorylation outer ear morphogenesis BMP signaling pathway response to lipopolysaccharide thyroid gland development response to epidermal growth factor positive regulation of MAP kinase activity positive regulation of telomerase activity peptidyl-tyrosine autophosphorylation sensory perception of pain positive regulation of cyclase activity trachea formation lipopolysaccharide-mediated signaling pathway intracellular signal transduction lung morphogenesis neural crest cell development transcription initiation from RNA polymerase I promoter regulation of early endosome to late endosome transport positive regulation of telomere maintenance via telomerase MAPK cascade positive regulation of histone acetylation axon guidance interleukin-1-mediated signaling pathway fibroblast growth factor receptor signaling pathway peptidyl-serine phosphorylation regulation of cellular response to heat Bergmann glial cell differentiation regulation of Golgi inheritance arachidonic acid metabolic process regulation of cytoskeleton organization positive regulation of transcription by RNA polymerase II regulation of phosphatidylinositol 3-kinase signaling regulation of ossification positive regulation of gene expression positive regulation of macrophage chemotaxis cellular response to amino acid starvation cellular response to reactive oxygen species stress-activated MAPK cascade cellular response to cadmium ion cellular response to dopamine positive regulation of metallopeptidase activity regulation of cellular pH protein-containing complex assembly cellular response to tumor necrosis factor regulation of gene expression cellular response to organic substance ageing decidualization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5595 26417 Ensembl ENSG00000102882 ENSMUSG00000063065 UniProt P27361 Q63844 RefSeq (mRNA) NM_001040056 NM_001109891 NM_002746 NM_011952 RefSeq (protein) NP_001035145 NP_001103361 NP_002737 NP_036082 Location (UCSC) Chr 16: 30.11 – 30.12 Mb Chr 7: 126.36 – 126.36 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAP kinase) family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.^[7]

Clinical significance

It has been suggested that MAPK3, along with the gene IRAK1, is turned off by two microRNAs that were activated after the influenza A virus had been made to infect human lung cells.^[8]

Signaling pathways

Pharmacological inhibition of ERK1/2 restores GSK3β activity and protein synthesis levels in a model of tuberous sclerosis.^[9]

Interactions

MAPK3 has been shown to interact with:

• DUSP3,^[10]
• DUSP6^[11]
• GTF2I,^[12]
• HDAC4,^[13]
• MAP2K1,^{[14][15][16][17]}
• MAP2K2,^[14][15][17]
• PTPN7,^[18][19][20]
• RPS6KA2,^[21][22] and
• SPIB.^[23]