MEOX2

Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene.^[5][6]

MEOX2
Identifiers
Aliases	MEOX2, GAX, MOX2, mesenchyme homeobox 2
External IDs	OMIM: 600535; MGI: 103219; HomoloGene: 4330; GeneCards: MEOX2; OMA:MEOX2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p21.2 Start 15,611,212 bp[1] End 15,686,683 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 A3|12 16.84 cM Start 37,158,539 bp[2] End 37,229,533 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon parietal pleura spinal ganglia tibial nerve synovial joint subcutaneous adipose tissue tendon of biceps brachii saphenous vein sural nerve trigeminal ganglion Top expressed in left lung lobe sciatic nerve lumbar spinal ganglion dermis hand foot ankle human fetus carotid body limb bud More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nuclear speck nucleus Biological process neuron death roof of mouth development regulation of transcription, DNA-templated somite specification blood circulation transcription, DNA-templated limb development multicellular organism development angiogenesis skeletal muscle tissue development positive regulation of transcription by RNA polymerase II negative regulation of cell migration involved in sprouting angiogenesis transcription by RNA polymerase II somite development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4223 17286 Ensembl ENSG00000106511 ENSMUSG00000036144 UniProt P50222 P32443 RefSeq (mRNA) NM_005924 NM_008584 RefSeq (protein) NP_005915 NP_032610 Location (UCSC) Chr 7: 15.61 – 15.69 Mb Chr 12: 37.16 – 37.23 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.^[6] MEOX2 has been implicated in the initiation of tumors in glioma.^[7] Additionally, MEOX2 influences several critical processes in lung cancer, including cellular proliferation, invasion, metastasis, angiogenesis, and the development of drug resistance.^[8][9]

Interactions

MEOX2 has been shown to interact with PAX1^[10] and PAX3.^[10]