MEPE

This article is about the gene and protein. For other uses, see mepe (disambiguation).

Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) is a protein that in humans is encoded by the MEPE gene.^[5][6] A conserved RGD motif is found in this protein, and this is potentially involved in integrin recognition.^[7]

MEPE
Identifiers
Aliases	MEPE, OF45, matrix extracellular phosphoglycoprotein
External IDs	OMIM: 605912; MGI: 2137384; HomoloGene: 10623; GeneCards: MEPE; OMA:MEPE - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q22.1 Start 87,821,398 bp[1] End 87,846,814 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E5 Start 104,473,195 bp[2] End 104,486,477 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia periodontal fiber trabecular bone cingulate gyrus anterior cingulate cortex Brodmann area 23 Brodmann area 9 prefrontal cortex middle temporal gyrus superior frontal gyrus Top expressed in body of femur tibiofemoral joint cochlea fossa vestibular labyrinth vestibular sensory epithelium efferent ductule sexually immature organism More reference expression data BioGPS More reference expression data
Gene ontology Molecular function extracellular matrix structural constituent protein binding extracellular matrix protein binding Cellular component extracellular region endoplasmic reticulum lumen extracellular matrix Biological process skeletal system development biomineral tissue development post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56955 94111 Ensembl ENSG00000152595 ENSMUSG00000053863 UniProt Q9NQ76 Q8K4L6 RefSeq (mRNA) NM_001184694 NM_001184695 NM_001184696 NM_001184697 NM_001291183 NM_020203 NM_053172 RefSeq (protein) NP_001171623 NP_001171624 NP_001171625 NP_001171626 NP_001278112 NP_064588 NP_444402 Location (UCSC) Chr 4: 87.82 – 87.85 Mb Chr 5: 104.47 – 104.49 Mb PubMed search [3] [4]
Wikidata
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Osteoregulin
Identifiers
Symbol	Osteoregulin
Pfam	PF07175
InterPro	IPR009837
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary