MERTK

Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene.^[5][6][7]

MERTK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DBJ, 2P0C, 3BPR, 3BRB, 3TCP, 4M3Q, 4MH7, 4MHA
Identifiers
Aliases	MERTK, MER, RP38, c-mer, Tyro12, c-Eyk, MER proto-oncogene, tyrosine kinase
External IDs	OMIM: 604705; MGI: 96965; HomoloGene: 4626; GeneCards: MERTK; OMA:MERTK - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q13 Start 111,898,607 bp[1] End 112,029,561 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F1 Start 128,540,876 bp[2] End 128,644,814 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex gastric mucosa left adrenal gland left adrenal cortex popliteal artery tibial arteries Descending thoracic aorta ascending aorta left coronary artery spleen Top expressed in stroma of bone marrow tunica media of zone of aorta retinal pigment epithelium jejunum ascending aorta ileum body of femur spleen duodenum right kidney More reference expression data BioGPS n/a
Gene ontology Molecular function ATP binding protein tyrosine kinase activity protein kinase activity protein binding transmembrane receptor protein tyrosine kinase activity kinase activity nucleotide binding transferase activity receptor tyrosine kinase transmembrane signaling receptor activity Wnt-protein binding Cellular component integral component of membrane photoreceptor outer segment rhabdomere membrane integral component of plasma membrane plasma membrane cytoplasm extracellular space receptor complex Biological process spermatogenesis vagina development protein kinase B signaling natural killer cell differentiation cell surface receptor signaling pathway protein phosphorylation platelet activation cell-cell signaling positive regulation of phagocytosis apoptotic cell clearance substrate adhesion-dependent cell spreading leukocyte migration negative regulation of lymphocyte activation phosphorylation retina development in camera-type eye negative regulation of leukocyte apoptotic process phagocytosis secretion by cell peptidyl-tyrosine phosphorylation negative regulation of cytokine production neutrophil clearance negative regulation of signal transduction Wnt signaling pathway cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade transmembrane receptor protein tyrosine kinase signaling pathway nervous system development cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10461 17289 Ensembl ENSG00000153208 ENSMUSG00000014361 UniProt Q12866 Q60805 RefSeq (mRNA) NM_006343 NM_008587 RefSeq (protein) NP_006334 NP_032613 Location (UCSC) Chr 2: 111.9 – 112.03 Mb Chr 2: 128.54 – 128.64 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).^[7]