METAP1

Methionine aminopeptidase 1 is an enzyme that in humans is encoded by the METAP1 gene.^[5][6][7]

METAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B3H, 2B3K, 2B3L, 2G6P, 2GZ5, 2NQ6, 2NQ7, 4FLI, 4FLJ, 4FLK, 4FLL, 4HXX, 4IKR, 4IKS, 4IKT, 4IKU, 4IU6, 4U1B, 4U69, 4U6C, 4U6E, 4U6J, 4U6W, 4U6Z, 4U70, 4U71, 4U73, 4U75, 4U76
Identifiers
Aliases	METAP1, MAP1A, MetAP1A, methionyl aminopeptidase 1
External IDs	OMIM: 610151; MGI: 1922874; HomoloGene: 6488; GeneCards: METAP1; OMA:METAP1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q23 Start 98,995,620 bp[1] End 99,062,813 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G3 Start 138,164,717 bp[2] End 138,195,276 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis endometrium Descending thoracic aorta epithelium of nasopharynx rectum urinary bladder gingival epithelium hair follicle oral cavity Top expressed in primitive streak lens vastus lateralis muscle triceps brachii muscle sternocleidomastoid muscle temporal muscle hair follicle crypt of lieberkuhn of small intestine digastric muscle ciliary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity aminopeptidase activity metalloexopeptidase activity hydrolase activity metal ion binding Cellular component cytosol cytoplasm Biological process peptidyl-methionine modification platelet aggregation N-terminal protein amino acid modification regulation of translation proteolysis regulation of rhodopsin mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23173 75624 Ensembl ENSG00000164024 ENSMUSG00000005813 UniProt P53582 Q8BP48 RefSeq (mRNA) NM_015143 NM_175224 RefSeq (protein) NP_055958 NP_780433 Location (UCSC) Chr 4: 99 – 99.06 Mb Chr 3: 138.16 – 138.2 Mb PubMed search [3] [4]
Wikidata
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