METTL14

Methyltransferase like 14 is a protein that in humans is encoded by the METTL14 gene. ^[5]

METTL14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5IL1, 5K7W, 5IL2, 5IL0, 5K7M, 5K7U
Identifiers
Aliases	METTL14, methyltransferase like 14, hmethyltransferase 14, N6-adenosine-methyltransferase subunit
External IDs	OMIM: 616504; MGI: 2442926; HomoloGene: 10865; GeneCards: METTL14; OMA:METTL14 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q26 Start 118,685,392 bp[1] End 118,715,433 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G1 Start 123,161,946 bp[2] End 123,179,757 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon secondary oocyte tail of epididymis islet of Langerhans caput epididymis corpus epididymis ventricular zone epithelium of colon thymus pancreatic epithelial cell Top expressed in hand ascending aorta aortic valve otolith organ utricle primitive streak tail of embryo efferent ductule epiblast supraoptic nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function RNA binding mRNA binding S-adenosyl-L-methionine binding protein binding mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity Cellular component RNA N6-methyladenosine methyltransferase complex nucleus nucleoplasm Biological process stem cell population maintenance mRNA splicing, via spliceosome mRNA destabilization mRNA methylation RNA methylation mRNA catabolic process spermatogenesis forebrain radial glial cell differentiation gliogenesis cell differentiation RNA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57721 210529 Ensembl ENSG00000145388 ENSMUSG00000028114 UniProt Q9HCE5 Q3UIK4 RefSeq (mRNA) NM_020961 NM_201638 RefSeq (protein) NP_066012 NP_964000 Location (UCSC) Chr 4: 118.69 – 118.72 Mb Chr 3: 123.16 – 123.18 Mb PubMed search [3] [4]
Wikidata
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