METTL16

RNA N6-adenosine-methyltransferase METTL16 is a protein that in humans is encoded by the METTL16 gene.^[5]

METTL16
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2H00
Identifiers
Aliases	METTL16, METT10D, methyltransferase like 16, methyltransferase 16, N6-methyladenosine
External IDs	MGI: 1914743; HomoloGene: 34653; GeneCards: METTL16; OMA:METTL16 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.3 Start 2,405,562 bp[1] End 2,511,891 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B5 Start 74,661,656 bp[2] End 74,719,351 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon gingival epithelium buccal mucosa cell sperm saphenous vein nipple urethra gonad germinal epithelium ventricular zone Top expressed in hand superior cervical ganglion otolith organ epiblast utricle supraoptic nucleus tail of embryo retinal pigment epithelium yolk sac mandibular prominence More reference expression data BioGPS n/a
Gene ontology Molecular function methyltransferase activity transferase activity 23S rRNA (adenine(1618)-N(6))-methyltransferase activity mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity U6 snRNA 3'-end binding RNA stem-loop binding U6 snRNA (adenine-(43)-N(6))-methyltransferase activity RNA binding mRNA (N6-adenosine)-methyltransferase activity Cellular component nucleus Biological process rRNA base methylation methylation posttranscriptional regulation of gene expression mRNA methylation snRNA (adenine-N6)-methylation mRNA processing RNA splicing regulation of mRNA splicing, via spliceosome RNA methylation mRNA catabolic process S-adenosylmethionine biosynthetic process mRNA destabilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79066 67493 Ensembl ENSG00000127804 ENSMUSG00000010554 UniProt Q86W50 Q9CQG2 RefSeq (mRNA) NM_024086 NM_026197 RefSeq (protein) NP_076991 NP_080473 Location (UCSC) Chr 17: 2.41 – 2.51 Mb Chr 11: 74.66 – 74.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• DNA/RNA methyltransferase
  • m⁶A methyltransferase complex
• N⁶-Methyladenosine (m⁶A)