MFGE8

Milk fat globule-EGF factor 8 protein (Mfge8), also known as lactadherin, is a protein that in humans is encoded by the MFGE8 gene.^[5][6]

MFGE8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L9L
Identifiers
Aliases	MFGE8, milk fat globule-EGF factor 8 protein, BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47, milk fat globule EGF and factor V/VIII domain containing
External IDs	OMIM: 602281; MGI: 102768; HomoloGene: 4334; GeneCards: MFGE8; OMA:MFGE8 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.1 Start 88,898,683 bp[1] End 88,913,468 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 D2|7 44.9 cM Start 78,783,516 bp[2] End 78,798,808 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Descending thoracic aorta ascending aorta right coronary artery left coronary artery popliteal artery tibial arteries stromal cell of endometrium left uterine tube apex of heart body of uterus Top expressed in lactiferous gland mesenteric lymph nodes tunica media of zone of aorta entorhinal cortex choroid plexus of fourth ventricle perirhinal cortex lacrimal gland ascending aorta molar neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylserine binding phosphatidylethanolamine binding integrin binding extracellular matrix structural constituent Cellular component external side of plasma membrane extrinsic component of plasma membrane extracellular region extracellular exosome extracellular matrix extracellular vesicle membrane extracellular space endoplasmic reticulum lumen collagen-containing extracellular matrix Biological process phagocytosis, recognition angiogenesis positive regulation of phagocytosis positive regulation of apoptotic cell clearance phagocytosis, engulfment cell adhesion single fertilization viral process post-translational protein modification apoptotic cell clearance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4240 17304 Ensembl ENSG00000140545 ENSMUSG00000030605 UniProt Q08431 P21956 RefSeq (mRNA) NM_001114614 NM_001310319 NM_001310320 NM_001310321 NM_005928 NM_001045489 NM_008594 RefSeq (protein) NP_001108086 NP_001297248 NP_001297249 NP_001297250 NP_005919 NP_001038954 NP_032620 Location (UCSC) Chr 15: 88.9 – 88.91 Mb Chr 7: 78.78 – 78.8 Mb PubMed search [3] [4]
Wikidata
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Species distribution

Mfge8 is a secreted protein found in vertebrates, including mammals as well as birds.

Function

MFGE8 may function as a cell adhesion protein to connect smooth muscle to elastic fibers in arteries.^[7] An amyloid fragment of MFGE8 known as medin accumulates in the aorta with aging.^[8] MFGE8 in the vasculature of adults can induce recovery from ischemia by facilitating angiogenesis.^[9] It has been suggested that antagonizing MFGE8-induced angiogenesis could be a way of fighting cancer.^[10]

MFGE8 contains a phosphatidylserine (PS) binding domain, as well as an arginine-glycine-aspartic acid motif, which enables the binding to integrins. MFGE8 binds PS, which is exposed on the surface of apoptotic cells.^[11] Opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells, mediates the engulfment of the dead cell.