MGST2

Microsomal glutathione S-transferase 2 is an enzyme that in humans is encoded by the MGST2 gene.^[5][6]

MGST2
Identifiers
Aliases	MGST2, GST2, MGST-II, microsomal glutathione S-transferase 2
External IDs	OMIM: 601733; MGI: 2448481; HomoloGene: 1811; GeneCards: MGST2; OMA:MGST2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.1 Start 139,665,768 bp[1] End 139,740,745 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 C Start 51,567,781 bp[2] End 51,590,098 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon secondary oocyte mucosa of esophagus rectum right lobe of liver gallbladder olfactory zone of nasal mucosa right adrenal cortex left adrenal gland apex of heart Top expressed in gastric mucosa epithelium of stomach mucous cell of stomach pyloric antrum granulocyte duodenum Paneth cell jejunum ileum left colon More reference expression data BioGPS n/a
Gene ontology Molecular function enzyme activator activity leukotriene-C4 synthase activity transferase activity glutathione transferase activity protein binding glutathione peroxidase activity Cellular component integral component of membrane intracellular membrane-bounded organelle organelle membrane plasma membrane cytoplasm endoplasmic reticulum membrane endoplasmic reticulum nuclear envelope membrane Biological process glutathione derivative biosynthetic process leukotriene metabolic process leukotriene biosynthetic process glutathione biosynthetic process response to lipopolysaccharide positive regulation of catalytic activity response to organonitrogen compound xenobiotic metabolic process cellular oxidant detoxification lipid metabolism membrane lipid catabolic process positive regulation of inflammatory response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4258 211666 Ensembl ENSG00000085871 ENSMUSG00000074604 UniProt Q99735 A2RST1 RefSeq (mRNA) NM_001204366 NM_001204367 NM_001204368 NM_002413 NM_174995 NM_001310482 RefSeq (protein) NP_001191295 NP_001191296 NP_001191297 NP_002404 NP_001297411 NP_778160 Location (UCSC) Chr 4: 139.67 – 139.74 Mb Chr 3: 51.57 – 51.59 Mb PubMed search [3] [4]
Wikidata
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The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4.^[6]