MICAL1

NEDD9-interacting protein with calponin homology and LIM domains is a protein that in humans is encoded by the MICAL1 gene.^[4][5]

MICAL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WYL, 2CO8
Identifiers
Aliases	MICAL1, MICAL, MICAL-1, NICAL, microtubule associated monooxygenase, calponin and LIM domain containing 1
External IDs	OMIM: 607129; MGI: 2385847; HomoloGene: 11246; GeneCards: MICAL1; OMA:MICAL1 - orthologs
Gene location (Mouse) Chr. Chromosome 10 (mouse)[1] Band 10|10 B1 Start 41,352,310 bp[1] End 41,363,028 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery left coronary artery canal of the cervix spleen left uterine tube popliteal artery ganglionic eminence stromal cell of endometrium right lung ascending aorta Top expressed in granulocyte lumbar spinal ganglion ascending aorta external carotid artery intestinal villus internal carotid artery tunica media of zone of aorta fossa Paneth cell sciatic nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding oxidoreductase activity actin binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen FAD binding protein binding metal ion binding protein kinase binding monooxygenase activity NAD(P)H oxidase H2O2-forming activity actin filament binding Cellular component cytoplasm cytoskeleton intermediate filament hippocampal mossy fiber expansion cytosol midbody intercellular bridge plasma membrane actin cytoskeleton Biological process negative regulation of protein phosphorylation actin filament depolymerization sulfur oxidation negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of apoptotic process cytoskeleton organization signal transduction regulation of regulated secretory pathway blood coagulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64780 171580 Ensembl n/a ENSMUSG00000019823 UniProt Q8TDZ2 Q8VDP3 RefSeq (mRNA) NM_022765 NM_001159291 NM_001286613 NM_001164433 NM_138315 NM_001358838 NM_001358839 RefSeq (protein) NP_001152763 NP_001273542 NP_073602 NP_001157905 NP_612188 NP_001345767 NP_001345768 Location (UCSC) n/a Chr 10: 41.35 – 41.36 Mb PubMed search [2] [3]
Wikidata
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Interactions

MICAL1 has been shown to interact with NEDD9^[4] and RAB1A.^[6]