MICAL3

Microtubule-associated monoxygenase, calponin and LIM domain containing 3, also known as MICAL3, is a human gene.^[5]

MICAL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D88
Identifiers
Aliases	MICAL3, MICAL-3, microtubule associated monooxygenase, calponin and LIM domain containing 3
External IDs	OMIM: 608882; MGI: 2442733; HomoloGene: 85288; GeneCards: MICAL3; OMA:MICAL3 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.21 Start 17,787,649 bp[1] End 18,024,561 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 F1 Start 120,931,707 bp[2] End 121,130,999 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve right uterine tube right hemisphere of cerebellum apex of heart body of uterus smooth muscle tissue epithelium of colon muscle layer of sigmoid colon left testis left uterine tube Top expressed in cumulus cell lip zygote superior frontal gyrus primary visual cortex muscle of thigh dentate gyrus of hippocampal formation granule cell cerebellar cortex tail of embryo genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function monooxygenase activity oxidoreductase activity actin binding FAD binding metal ion binding protein binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Cellular component plasma membrane cytoskeleton nucleus nucleoplasm cytoplasm cytosol spindle cell cortex midbody cell projection Biological process actin filament depolymerization cytoskeleton organization exocytosis cell cycle cell division Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57553 194401 Ensembl ENSG00000243156 ENSMUSG00000051586 UniProt Q7RTP6 Q8CJ19 RefSeq (mRNA) NM_001122731 NM_001136004 NM_015241 NM_020793 NM_001270475 NM_153396 RefSeq (protein) NP_001116203 NP_001129476 NP_056056 NP_001257404 NP_700445 Location (UCSC) Chr 22: 17.79 – 18.02 Mb Chr 6: 120.93 – 121.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Along with two other Rab proteins, Rab6 and Rab8, MICAL3 work together in the process of docking and fusing of vesicles that are involved in exocytosis.^[6]