MINPP1

Multiple inositol polyphosphate phosphatase 1 is an enzyme that in humans is encoded by the MINPP1 gene.^[5][6]

MINPP1
Identifiers
Aliases	MINPP1, HIPER1, MINPP2, MIPP, multiple inositol-polyphosphate phosphatase 1, PCH16
External IDs	OMIM: 605391; MGI: 1336159; HomoloGene: 37980; GeneCards: MINPP1; OMA:MINPP1 - orthologs
EC number	3.1.3.80
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.2 Start 87,504,875 bp[1] End 87,553,461 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C1|19 27.25 cM Start 32,463,169 bp[2] End 32,492,764 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone tibia islet of Langerhans Epithelium of choroid plexus jejunal mucosa right adrenal cortex gonad kidney tubule left adrenal gland stromal cell of endometrium Top expressed in fetal liver hematopoietic progenitor cell abdominal wall primitive streak molar seminal vesicula endocardial cushion skin of back decidua epiblast right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatase activity bisphosphoglycerate 3-phosphatase activity inositol-hexakisphosphate phosphatase activity hydrolase activity inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity inositol hexakisphosphate 2-phosphatase activity acid phosphatase activity inositol phosphate phosphatase activity protein histidine phosphatase activity Cellular component endoplasmic reticulum lumen endoplasmic reticulum extracellular exosome Biological process bone mineralization polyphosphate metabolic process inositol phosphate metabolic process ossification dephosphorylation protein dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9562 17330 Ensembl ENSG00000107789 ENSMUSG00000024896 UniProt Q9UNW1 Q9Z2L6 RefSeq (mRNA) NM_001178117 NM_001178118 NM_004897 NM_010799 RefSeq (protein) NP_001171588 NP_001171589 NP_004888 NP_034929 Location (UCSC) Chr 10: 87.5 – 87.55 Mb Chr 19: 32.46 – 32.49 Mb PubMed search [3] [4]
Wikidata
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MINPP1 hydrolyzes the abundant metabolites inositol pentakisphosphate and inositol hexakisphosphate and, like PTEN (MIM 601728), has the ability to remove 3-phosphate from inositol phosphate substrates.[supplied by OMIM]^[6]