MIR7-1

MicroRNA 7-1 is a microRNA molecule that in humans is encoded by the MIR7-1 gene.^[3]

MIR7-1
Identifiers
Aliases	MIR7-1, MIRN7-1, hsa-mir-7-1, mir-7-1, MicroRNA 7-1
External IDs	OMIM: 615239; GeneCards: MIR7-1; OMA:MIR7-1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q21.32 Start 83,969,748 bp[1] End 83,969,857 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg human kidney blood adrenal gland liver left lobe of thyroid gland tibial arteries adipose tissue body of pancreas islet of Langerhans n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 407043 n/a Ensembl ENSG00000284179 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 9: 83.97 – 83.97 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

microRNAs, or miRNAs, are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].