MKNK1

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.^[5][6]

MKNK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HW6, 2Y9Q
Identifiers
Aliases	MKNK1, MNK1, MAP kinase interacting serine/threonine kinase 1, MAPK interacting serine/threonine kinase 1
External IDs	OMIM: 606724; MGI: 894316; HomoloGene: 37838; GeneCards: MKNK1; OMA:MKNK1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p33 Start 46,557,407 bp[1] End 46,616,843 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D1 Start 115,696,395 bp[2] End 115,736,447 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas spleen Descending thoracic aorta blood gastric mucosa secondary oocyte muscle layer of sigmoid colon right coronary artery upper lobe of left lung monocyte Top expressed in granulocyte secondary oocyte stroma of bone marrow primary oocyte neural layer of retina thymus lip muscle of thigh pancreas dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity calcium-dependent protein serine/threonine kinase activity calmodulin binding kinase activity protein binding calmodulin-dependent protein kinase activity ATP binding protein serine/threonine kinase activity metal ion binding Cellular component cytoplasm cytosol nucleoplasm nucleus Biological process intracellular signal transduction phosphorylation protein phosphorylation protein autophosphorylation regulation of translation peptidyl-serine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8569 17346 Ensembl ENSG00000079277 ENSMUSG00000028708 UniProt Q9BUB5 O08605 RefSeq (mRNA) NM_001135553 NM_003684 NM_198973 NM_001377337 NM_001377338 NM_001377341 NM_001377342 NM_001377343 NM_001377373 NM_001377374 NM_001377375 NM_001285487 NM_001285488 NM_021461 NM_001355174 NM_001369238 RefSeq (protein) NP_001129025 NP_003675 NP_945324 NP_001364266 NP_001364267 NP_001364270 NP_001364271 NP_001364272 NP_001364302 NP_001364303 NP_001364304 NP_001272416 NP_001272417 NP_067436 NP_001342103 NP_001356167 Location (UCSC) Chr 1: 46.56 – 46.62 Mb Chr 4: 115.7 – 115.74 Mb PubMed search [3] [4]
Wikidata
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Interactions

MKNK1 has been shown to interact with MAPK1^[7] and Eukaryotic translation initiation factor 4 gamma.^[8]