MKNK2

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.^[5][6]

MKNK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AC3, 2AC5
Identifiers
Aliases	MKNK2, GPRK7, MNK2, MAP kinase interacting serine/threonine kinase 2, MAPK interacting serine/threonine kinase 2
External IDs	OMIM: 605069; MGI: 894279; HomoloGene: 49674; GeneCards: MKNK2; OMA:MKNK2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 2,037,465 bp[1] End 2,051,244 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 80,501,161 bp[2] End 80,513,946 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superior surface of tongue parotid gland body of tongue mucosa of pharynx amniotic fluid gastrocnemius muscle buccal mucosa cell skin of thigh tibialis anterior muscle Skeletal muscle tissue of rectus abdominis Top expressed in subcutaneous adipose tissue brown adipose tissue temporal muscle ankle digastric muscle white adipose tissue tunica adventitia of aorta intercostal muscle sternocleidomastoid muscle triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity calcium-dependent protein serine/threonine kinase activity metal ion binding calmodulin binding kinase activity protein serine/threonine kinase activity protein binding calmodulin-dependent protein kinase activity ATP binding Cellular component cytoplasm PML body nuclear body nucleus nucleoplasm Biological process intracellular signal transduction phosphorylation protein phosphorylation cell surface receptor signaling pathway cellular response to arsenic-containing substance peptidyl-serine phosphorylation extrinsic apoptotic signaling pathway in absence of ligand protein autophosphorylation regulation of translation apoptotic process hemopoiesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2872 17347 Ensembl ENSG00000099875 ENSMUSG00000020190 UniProt Q9HBH9 Q8CDB0 RefSeq (mRNA) NM_199054 NM_017572 NM_021462 RefSeq (protein) NP_060042 NP_951009 NP_067437 Location (UCSC) Chr 19: 2.04 – 2.05 Mb Chr 10: 80.5 – 80.51 Mb PubMed search [3] [4]
Wikidata
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Interactions

MNK2 has been shown to interact with MAPK1^[7][8] and Eukaryotic translation initiation factor 4 gamma.^[7]

MNK2 has been identified as a therapeutic target for diabetes. Specifically, blocking MNK2 interaction with eIF4G has been shown to boost protein synthesis and promote beta cell regeneration.^[9]