MKRN3

Makorin ring finger protein 3 is a protein that in humans is encoded by the MKRN3 gene.^[5]

MKRN3
Identifiers
Aliases	MKRN3, CPPB2, D15S9, RNF63, ZFP127, ZNF127, makorin ring finger protein 3
External IDs	OMIM: 603856; MGI: 2181178; HomoloGene: 4143; GeneCards: MKRN3; OMA:MKRN3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q11.2 Start 23,565,674 bp[1] End 23,630,075 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 C|7 34.37 cM Start 62,067,341 bp[2] End 62,069,887 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence testicle ventricular zone C1 segment corpus callosum amygdala minor salivary glands putamen prefrontal cortex caudate nucleus Top expressed in medial ganglionic eminence stellate ganglion thoracic ganglia superior cervical ganglion ventricular zone trigeminal ganglion embryo neural tube greater petrosal nerve embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding transferase activity identical protein binding Cellular component ribonucleoprotein complex Biological process protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7681 22652 Ensembl ENSG00000179455 ENSMUSG00000070527 UniProt Q13064 Q6NSB6 Q60764 RefSeq (mRNA) NM_005664 NM_011746 RefSeq (protein) NP_005655 NP_035876 Location (UCSC) Chr 15: 23.57 – 23.63 Mb Chr 7: 62.07 – 62.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. This gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader–Willi syndrome. An antisense RNA of unknown function has been found overlapping this gene.^{[citation needed]}