ML-154

ML-154 (NCGC-84) is a drug which acts as a selective, non-peptide antagonist at the neuropeptide S receptor NPSR.^[1] In animal studies it decreases self-administration of alcohol in addicted rats, and lowers motivation for alcohol rewards, suggesting a potential application for NPS antagonists in the treatment of alcoholism.^[2]

ML-154

Clinical data
ATC code	none
Identifiers
IUPAC name 3-(Diphenylphosphinothioyl)-2-methyl-1-[(2E)-3-phenyl-2-propen-1-yl]imidazo[1,2-a]pyridinium bromide
CAS Number	1345964-89-7
PubChem CID	46930969
ChemSpider	26360842
UNII	QF6BKX96N5
CompTox Dashboard (EPA)	DTXSID901032908
Chemical and physical data
Formula	C29H26BrN2PS
Molar mass	545.48 g·mol−1
3D model (JSmol)	Interactive image
SMILES [Br-].C1(=CC=CC=C1)[P](=S)(C2=C([N+](=C3C=CC=C[N]23)C\C=C\C4=CC=CC=C4)C)C5=CC=CC=C5
InChI InChI=1S/C29H26N2PS.BrH/c1-24-29(32(33,26-17-7-3-8-18-26)27-19-9-4-10-20-27)31-22-12-11-21-28(31)30(24)23-13-16-25-14-5-2-6-15-25;/h2-22H,23H2,1H3;1H/q+1;/p-1/b16-13+; Key:CJAQCMBWGUOBIX-ZUQRMPMESA-M

See also

• Neuropeptide S receptor