MMEL1

Membrane metallo-endopeptidase-like 1 is a protein that in humans is encoded by the MMEL1 gene.^[5]

MMEL1
Identifiers
Aliases	MMEL1, MMEL2, NEP2, NEPII, NL1, NL2, SEP, membrane metallo-endopeptidase-like 1, membrane metalloendopeptidase like 1
External IDs	OMIM: 618104; MGI: 1351603; HomoloGene: 22778; GeneCards: MMEL1; OMA:MMEL1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.32 Start 2,590,639 bp[1] End 2,633,016 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 154,954,042 bp[2] End 154,979,985 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad left testis right testis mucosa of transverse colon right uterine tube body of stomach duodenum right lung fundus Top expressed in spermatid seminiferous tubule spermatocyte embryo embryo neural layer of retina blastocyst facial motor nucleus epiblast cerebellar cortex More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity metalloendopeptidase activity hydrolase activity metallopeptidase activity metal ion binding endopeptidase activity Cellular component integral component of membrane extracellular region membrane extracellular space Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79258 27390 Ensembl ENSG00000142606 ENSG00000277131 ENSMUSG00000058183 UniProt Q495T6 Q9JLI3 RefSeq (mRNA) NM_033467 NM_013783 RefSeq (protein) NP_258428 NP_038811 Location (UCSC) Chr 1: 2.59 – 2.63 Mb Chr 4: 154.95 – 154.98 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart.