MMP16

Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene.^[5][6]

MMP16
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RM8
Identifiers
Aliases	MMP16, C8orf57, MMP-X2, MT-MMP2, MT-MMP3, MT3-MMP, matrix metallopeptidase 16
External IDs	OMIM: 602262; MGI: 1276107; HomoloGene: 55939; GeneCards: MMP16; OMA:MMP16 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.3 Start 88,032,011 bp[1] End 88,328,025 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A3|4 7.08 cM Start 17,852,893 bp[2] End 18,119,145 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell tibia Brodmann area 23 cartilage tissue postcentral gyrus middle temporal gyrus entorhinal cortex superior frontal gyrus stromal cell of endometrium ventricular zone Top expressed in calvaria body wall rib body of femur genital tubercle umbilical cord Rostral migratory stream lumbar subsegment of spinal cord tail of embryo pineal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding peptidase activity enzyme activator activity hydrolase activity metallopeptidase activity metalloendopeptidase activity zinc ion binding metalloaminopeptidase activity Cellular component integral component of membrane membrane extracellular matrix plasma membrane extracellular region cell surface Golgi lumen integral component of plasma membrane extracellular space Biological process ossification extracellular matrix disassembly endochondral ossification craniofacial suture morphogenesis chondrocyte proliferation collagen catabolic process embryonic cranial skeleton morphogenesis bone development positive regulation of catalytic activity proteolysis protein processing protein metabolic process skeletal system development extracellular matrix organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4325 17389 Ensembl ENSG00000156103 ENSMUSG00000028226 UniProt P51512 Q9WTR0 RefSeq (mRNA) NM_005941 NM_022564 NM_032297 NM_019724 NM_001379518 NM_001379519 RefSeq (protein) NP_005932 NP_062698 NP_001366447 NP_001366448 Location (UCSC) Chr 8: 88.03 – 88.33 Mb Chr 4: 17.85 – 18.12 Mb PubMed search [3] [4]
Wikidata
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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene produces at least two transcripts, one which encodes a membrane-bound form and another a soluble form of the protein. Both forms of the protein activate MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.^[6]