MMP17

Matrix metalloproteinase-17 (MMP-17) also known as membrane-type matrix metalloproteinase 4 (MT-MMP 4) is an enzyme that in humans is encoded by the MMP17 gene.^[5][6]

MMP17
Identifiers
Aliases	MMP17, MT4-MMP, MMP-17, MT4MMP, MTMMP4, matrix metallopeptidase 17
External IDs	OMIM: 602285; MGI: 1346076; HomoloGene: 22669; GeneCards: MMP17; OMA:MMP17 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.33 Start 131,828,393 bp[1] End 131,851,783 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G1.3|5 68.18 cM Start 129,661,233 bp[2] End 129,688,163 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe anterior cingulate cortex nucleus accumbens prefrontal cortex caudate nucleus putamen Brodmann area 9 amygdala granulocyte tibial nerve Top expressed in primary motor cortex dentate gyrus olfactory tubercle prefrontal cortex subiculum ascending aorta dentate gyrus of hippocampal formation granule cell CA3 field anterior amygdaloid area hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metallopeptidase activity enzyme activator activity metal ion binding peptidase activity hydrolase activity zinc ion binding metalloendopeptidase activity metalloaminopeptidase activity Cellular component integral component of plasma membrane membrane extracellular region extracellular matrix anchored component of membrane plasma membrane extracellular space Biological process drinking behavior positive regulation of catalytic activity kidney development proteolysis extracellular matrix organization collagen catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4326 23948 Ensembl ENSG00000198598 ENSMUSG00000029436 UniProt Q9ULZ9 Q8IWC3 Q9R0S3 RefSeq (mRNA) NM_016155 NM_011846 RefSeq (protein) NP_057239 NP_057239.4 NP_035976 Location (UCSC) Chr 12: 131.83 – 131.85 Mb Chr 5: 129.66 – 129.69 Mb PubMed search [3] [4]
Wikidata
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Function

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. MMP17 and MMP25 are to this day the only known GPI-anchored membrane-type MMPs, opposite to the more common transmembrane MMPs. The protein activates MMP2 by cleavage.^[6]

In melanocytic cells MMP17 gene expression may be regulated by MITF.^[7]