MMP19

Matrix metalloproteinase-19 (MMP-19) also known as matrix metalloproteinase RASI is an enzyme that in humans is encoded by the MMP19 gene.^[5][6]

MMP19
Identifiers
Aliases	MMP19, MMP18, RASI-1, CODA, matrix metallopeptidase 19
External IDs	OMIM: 601807; MGI: 1927899; HomoloGene: 1820; GeneCards: MMP19; OMA:MMP19 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.2 Start 55,835,433 bp[1] End 55,842,966 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D3|10 77.16 cM Start 128,626,779 bp[2] End 128,636,693 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left uterine tube gallbladder olfactory bulb upper lobe of left lung spleen ascending aorta stromal cell of endometrium Descending thoracic aorta smooth muscle tissue right ovary Top expressed in liver stroma of bone marrow blood left lobe of liver adrenal gland uterus aortic valve ascending aorta muscle of thigh umbilical cord More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding metal ion binding peptidase activity hydrolase activity metallopeptidase activity metalloendopeptidase activity serine-type endopeptidase activity Cellular component extracellular region extracellular matrix extracellular space Biological process cell differentiation ovulation from ovarian follicle extracellular matrix disassembly luteolysis proteolysis multicellular organism development angiogenesis ovarian follicle development response to hormone response to cAMP collagen catabolic process extracellular matrix organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4327 58223 Ensembl ENSG00000123342 ENSMUSG00000025355 UniProt Q99542 Q9JHI0 RefSeq (mRNA) NM_001032360 NM_001272101 NM_002429 NM_022790 NM_022792 NM_001164197 NM_021412 RefSeq (protein) NP_001259030 NP_002420 NP_001157669 NP_067387 Location (UCSC) Chr 12: 55.84 – 55.84 Mb Chr 10: 128.63 – 128.64 Mb PubMed search [3] [4]
Wikidata
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Function

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This protein is expressed in human epidermis and endothelial cells and it has a role in cellular proliferation, migration, angiogenesis and adhesion. Multiple transcript variants encoding distinct isoforms have been identified for this gene.^[6]