MMP21

Matrix metalloproteinase-21 (MMP-21) is an enzyme that in humans is encoded by the MMP21 gene.^[5][6]

MMP21
Identifiers
Aliases	MMP21, MMP-21, HTX7, matrix metallopeptidase 21
External IDs	OMIM: 608416; MGI: 2664387; HomoloGene: 17519; GeneCards: MMP21; OMA:MMP21 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.2 Start 125,753,580 bp[1] End 125,775,821 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 133,275,999 bp[2] End 133,281,790 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad corpus epididymis testicle left ovary right ovary body of pancreas minor salivary glands ectocervix right auricle of heart right uterine tube Top expressed in embryo blastocyst right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metallopeptidase activity metal ion binding zinc ion binding metalloendopeptidase activity peptidase activity hydrolase activity Cellular component extracellular region extracellular matrix Biological process hematopoietic progenitor cell differentiation proteolysis coronary vasculature development determination of left/right symmetry determination of heart left/right asymmetry extracellular matrix organization collagen catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 118856 214766 Ensembl ENSG00000154485 ENSMUSG00000030981 UniProt Q8N119 Q8K3F2 RefSeq (mRNA) NM_147191 NM_152944 NM_001320216 RefSeq (protein) NP_671724 NP_001307145 NP_694423 Location (UCSC) Chr 10: 125.75 – 125.78 Mb Chr 7: 133.28 – 133.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival.^[6]