MMP23B

Matrix metalloproteinase-23 is an enzyme that in humans is encoded by the MMP23B gene.^[5][6][7]

MMP23B
Identifiers
Aliases	MMP23B, MIFR, MIFR-1, MMP22, MMP23A, matrix metallopeptidase 23B
External IDs	OMIM: 603321; MGI: 1347361; HomoloGene: 3424; GeneCards: MMP23B; OMA:MMP23B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.33 Start 1,632,163 bp[1] End 1,635,263 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 155,735,112 bp[2] End 155,737,841 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right ovary left uterine tube right coronary artery left ovary left ventricle thoracic aorta ascending aorta Descending thoracic aorta granulocyte Top expressed in ascending aorta aortic valve calvaria uterus stroma of bone marrow tunica media of zone of aorta body of femur renal corpuscle pericardial cavity efferent ductule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding peptidase activity metalloendopeptidase activity hydrolase activity metallopeptidase activity metal ion binding Cellular component integral component of membrane intracellular anatomical structure endoplasmic reticulum membrane endoplasmic reticulum membrane extracellular matrix collagen-containing extracellular matrix extracellular space Biological process reproduction proteolysis extracellular matrix organization collagen catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8510 26561 Ensembl ENSG00000189409 ENSMUSG00000029061 UniProt O75900 O88676 RefSeq (mRNA) NM_006983 NM_011985 NM_001320235 RefSeq (protein) NP_008914 NP_001307164 NP_036115 Location (UCSC) Chr 1: 1.63 – 1.64 Mb Chr 4: 155.74 – 155.74 Mb PubMed search [3] [4]
Wikidata
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Function

This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the copy of the duplicated region of the gene that is closer to the end of the chromosome (more telemeric).^[7]

MMP23B is strongly expressed in ovary and heart.^[8]