MMP8

Neutrophil collagenase, also known as matrix metalloproteinase-8 (MMP-8) or PMNL collagenase (MNL-CL), is a collagen cleaving enzyme which is present in the connective tissue of most mammals.^[5] In humans, the MMP-8 protein is encoded by the MMP8 gene.^[6][7] The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.^[5] Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage.

MMP8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A86, 1JAP, 1I76, 1ZVX, 3TT4, 2OY2, 1ZS0, 1JAN, 1MMB, 1I73, 1A85, 1KBC, 1ZP5, 1JH1, 3DPF, 1JAQ, 3DPE, 1BZS, 4QKZ, 1JAO, 3DNG, 2OY4, 1MNC
Identifiers
Aliases	MMP8, CLG1, HNC, MMP-8, PMNL-CL, matrix metallopeptidase 8
External IDs	OMIM: 120355; MGI: 1202395; HomoloGene: 22482; GeneCards: MMP8; OMA:MMP8 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q22.2 Start 102,711,796 bp[1] End 102,727,050 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A1 Start 7,558,457 bp[2] End 7,568,486 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone bone marrow bone marrow cells testicle monocyte blood amniotic fluid spleen granulocyte upper lobe of left lung Top expressed in granulocyte tibiofemoral joint muscle of thorax third toe bone marrow blood second toe cartilage tissue hallux bones of free part of lower limb More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding peptidase activity hydrolase activity metallopeptidase activity metal ion binding serine-type endopeptidase activity metalloendopeptidase activity endopeptidase activity Cellular component extracellular matrix extracellular region specific granule lumen tertiary granule lumen extracellular space collagen-containing extracellular matrix Biological process collagen catabolic process extracellular matrix disassembly endodermal cell differentiation proteolysis neutrophil degranulation positive regulation of gene expression negative regulation of gene expression negative regulation of interleukin-10 production positive regulation of interleukin-6 production positive regulation of DNA binding positive regulation of MAPK cascade positive regulation of nitric oxide biosynthetic process positive regulation of JNK cascade regulation of neuroinflammatory response positive regulation of neuroinflammatory response positive regulation of NIK/NF-kappaB signaling positive regulation of reactive oxygen species biosynthetic process regulation of microglial cell activation positive regulation of microglial cell activation extracellular matrix organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4317 17394 Ensembl ENSG00000118113 ENSMUSG00000005800 UniProt P22894 O70138 RefSeq (mRNA) NM_001304441 NM_001304442 NM_002424 NM_008611 RefSeq (protein) NP_001291370 NP_001291371 NP_002415 NP_032637 Location (UCSC) Chr 11: 102.71 – 102.73 Mb Chr 9: 7.56 – 7.57 Mb PubMed search [3] [4]
Wikidata
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Function

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The primary function of MMP-8 is the degradation of type I, II and III collagens. In cancer, loss of MMP-8 in the murine MMTV-PyMT breast cancer model has been associated with increased tumor growth and metastatic burden, as well as enhanced tumor vascularity and altered immune cell infiltration.^[8] Furthermore, analysis of MMP-8 in breast cancer cell lines revealed a causal connection between MMP-8 activity and IL6 and IL8 production, suggesting a role for MMP-8 in the regulation of the innate immune system.^[9]