MNT (gene)

MNT (Max-binding protein MNT) is a Max-binding protein that is encoded by the MNT gene^[5][6][7]

MNT
Identifiers
Aliases	MNT, MAD6, MXD6, ROX, bHLHd3, MAX network transcriptional repressor, lncRNA-HAL
External IDs	OMIM: 603039; MGI: 109150; HomoloGene: 7842; GeneCards: MNT; OMA:MNT - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.3 Start 2,384,073 bp[1] End 2,401,104 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 45.76 cM Start 74,721,746 bp[2] End 74,736,551 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 middle temporal gyrus Region I of hippocampus proper endothelial cell dorsal motor nucleus of vagus nerve Brodmann area 10 sural nerve gingival epithelium orbitofrontal cortex tendon of biceps brachii Top expressed in Rostral migratory stream motor neuron stroma of bone marrow iris ciliary body gastrula vestibular membrane of cochlear duct substantia nigra blood aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding transcription coactivator activity RNA polymerase II transcription regulatory region sequence-specific DNA binding chromatin binding protein dimerization activity DNA-binding transcription repressor activity, RNA polymerase II-specific transcription corepressor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process multicellular organism development negative regulation of apoptotic signaling pathway regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription, DNA-templated negative regulation of cell population proliferation regulation of cell cycle positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4335 17428 Ensembl ENSG00000070444 ENSMUSG00000000282 UniProt Q99583 O08789 RefSeq (mRNA) NM_020310 NM_010813 RefSeq (protein) NP_064706 NP_034943 Location (UCSC) Chr 17: 2.38 – 2.4 Mb Chr 11: 74.72 – 74.74 Mb PubMed search [3] [4]
Wikidata
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Function

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. Its delta signature is 44. This protein is a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA and recruiting Sin3 corepressor proteins through its N-terminal Sin3-interaction domain ^[5][8]

Interactions

MNT (gene) has been shown to interact with MLX,^[9][10] SIN3A^[11] and MAX.^[11]