MOBKL1A

Mps one binder kinase activator-like 1A, also known as Mob1 homolog 1A, is a protein that in humans is encoded by the MOBKL1A gene.^[5][6]

MOB1B
Identifiers
Aliases	MOB1B, MATS2, MOB4A, MOBKL1A, MOB kinase activator 1B
External IDs	OMIM: 609282; MGI: 1915723; HomoloGene: 61676; GeneCards: MOB1B; OMA:MOB1B - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.3 Start 70,902,326 bp[1] End 71,022,449 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E1 Start 88,868,714 bp[2] End 88,912,079 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla thymus superior surface of tongue saphenous vein skin of arm trabecular bone Medulla Oblongata trigeminal ganglion superior vestibular nucleus body of tongue Top expressed in superior surface of tongue gallbladder seminal vesicula Epithelium of choroid plexus left lobe of liver aortic valve ascending aorta ciliary body atrioventricular valve epithelium of stomach More reference expression data BioGPS n/a
Gene ontology Molecular function kinase binding protein binding kinase activator activity metal ion binding Cellular component cytoplasm extracellular exosome nucleus nucleolus cytosol Biological process regulation of protein autophosphorylation hippo signaling positive regulation of phosphorylation positive regulation of kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 92597 68473 Ensembl ENSG00000173542 ENSMUSG00000006262 UniProt Q7L9L4 Q8BPB0 RefSeq (mRNA) NM_001244766 NM_001244767 NM_173468 NM_026735 RefSeq (protein) NP_001231695 NP_001231696 NP_775739 NP_081011 Location (UCSC) Chr 4: 70.9 – 71.02 Mb Chr 5: 88.87 – 88.91 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation.^[5]

See also

• Hippo signaling pathway