MOCS3

Adenylyltransferase and sulfurtransferase MOCS3 is an enzyme that in humans is encoded by the MOCS3 gene.^[5][6]

MOCS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3I2V
Identifiers
Aliases	MOCS3, UBA4, molybdenum cofactor synthesis 3
External IDs	OMIM: 609277; MGI: 1916622; HomoloGene: 6108; GeneCards: MOCS3; OMA:MOCS3 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.13 Start 50,958,818 bp[1] End 50,963,929 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 168,072,542 bp[2] End 168,074,514 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm testicle stromal cell of endometrium gonad ventricular zone ganglionic eminence islet of Langerhans gastrocnemius muscle nasal epithelium prefrontal cortex Top expressed in seminiferous tubule spermatid spermatocyte muscle of thigh right kidney granulocyte embryo primary visual cortex proximal tubule mesenteric lymph nodes More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding thiosulfate sulfurtransferase activity molybdopterin-synthase sulfurtransferase activity metal ion binding URM1 activating enzyme activity protein binding catalytic activity ubiquitin-like modifier activating enzyme activity ATP binding molybdopterin-synthase adenylyltransferase activity nucleotidyltransferase activity sulfurtransferase activity Cellular component cytoplasm cytosol Biological process molybdopterin cofactor biosynthetic process tRNA processing Mo-molybdopterin cofactor biosynthetic process metabolism tRNA wobble uridine modification tRNA thio-modification tRNA wobble position uridine thiolation protein urmylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27304 69372 Ensembl ENSG00000124217 ENSMUSG00000074576 UniProt O95396 A2BDX3 RefSeq (mRNA) NM_014484 NM_001160330 RefSeq (protein) NP_055299 NP_001153802 Location (UCSC) Chr 20: 50.96 – 50.96 Mb Chr 2: 168.07 – 168.07 Mb PubMed search [3] [4]
Wikidata
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Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. One of the enzymes required for the biosynthesis of MoCo is molybdopterin synthase (MPT synthase, encoded by MOCS2/Mocs2 in mammals). The protein encoded by this gene adenylates and activates MPT synthase. This gene contains no introns. A pseudogene of this gene is present on chromosome 14.^[6]