MOV10

Putative helicase MOV-10 is an enzyme that in humans is encoded by the MOV10 gene.^[5] Stability of MOV10 protein is controlled via DCAF12 ubiquitin ligase.^[6]

MOV10
Identifiers
Aliases	MOV10, fSAP113, gb110, Mov10 RISC complex RNA helicase
External IDs	OMIM: 610742; MGI: 97054; HomoloGene: 10365; GeneCards: MOV10; OMA:MOV10 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.2 Start 112,673,141 bp[1] End 112,700,756 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.2 Start 104,702,152 bp[2] End 104,725,879 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis right uterine tube anterior pituitary right lobe of liver granulocyte skin of arm skin of abdomen mucosa of transverse colon right adrenal cortex Top expressed in blastocyst granulocyte tail of embryo yolk sac genital tubercle gallbladder duodenum ankle joint zygote ileum More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding helicase activity protein binding hydrolase activity ATP binding RNA binding 5'-3' RNA helicase activity Cellular component cytoplasm P-body extracellular space cytosol nucleus cytoplasmic stress granule cytoplasmic ribonucleoprotein granule P granule Biological process regulation of transcription, DNA-templated transcription, DNA-templated mRNA destabilization-mediated gene silencing by miRNA gene silencing Wnt signaling pathway, calcium modulating pathway gene silencing by miRNA regulation of megakaryocyte differentiation negative regulation of transposition, RNA-mediated positive regulation of gene expression negative regulation of gene expression RNA interference positive regulation of mRNA catabolic process 3'-UTR-mediated mRNA destabilization regulation of neuron projection arborization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4343 17454 Ensembl ENSG00000155363 ENSMUSG00000002227 UniProt Q9HCE1 P23249 RefSeq (mRNA) NM_001130079 NM_001286072 NM_020963 NM_001321324 NM_001369507 NM_001389562 NM_001389563 NM_001163440 NM_001163441 NM_008619 RefSeq (protein) NP_001123551 NP_001273001 NP_001308253 NP_066014 NP_001356436 NP_001156912 NP_001156913 NP_032645 Location (UCSC) Chr 1: 112.67 – 112.7 Mb Chr 3: 104.7 – 104.73 Mb PubMed search [3] [4]
Wikidata
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