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MPD-75
Pharmaceutical compound From Wikipedia, the free encyclopedia
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MPD-75, also known as 1-methyl-N-pyrrolidyllysergamide or as 1-methyllysergic acid pyrrolidide, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).[1][2][3][4] It is the 1-methyl derivative of lysergic acid pyrrolidide (LA-Pyr; LPD-824) and the N-pyrrolidide analogue of 1-methyl-LSD (MLD-41).[2]
The drug was evaluated in humans and was found to produce partial LSD-like effects.[2][3][4] It was reported to have had a faster onset and shorter duration compared to LSD.[2] MPD-75 showed less than 5% of the potency of LSD in producing LSD-like effects, with a required dose of >20 μg/kg or >1.6 mg orally.[2][5][3][4] According to another source however, MPD-75 had 7% of the potency of LSD in humans.[6] For comparison, LA-Pyr had approximately 10% of the potency of LSD and had more full LSD-like effects, while 1-methyl-LSD had 33% of the potency of LSD and likewise produced full LSD-like effects.[2][3][4]
In animal studies, MPD-75 had 4% of the toxicity of LSD in rabbits (presumably in terms of LD50 ), 0% of its pyretogenic activity in rabbits, and 130% of its antiserotonergic activity in the isolated rat uterus.[6][7]
MPD-75 was first described in the scientific literature by Albert Hofmann and colleagues by 1957.[8][9] It has not been encountered as a designer drug as of 2020.[8]
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See also
- Substituted lysergamide
- Lysergic acid pyrrolidide (LA-Pyr; LPD-824)
References
External links
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