MRGPRX2

Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene.^[5][6] It is most abundant on cutaneous mast cells, sensory neurons, and keratinocytes.^[7]

MRGPRX2
Identifiers
Aliases	MRGPRX2, MGRG3, MRGX2, MAS related GPR family member X2
External IDs	OMIM: 607228; MGI: 3588270; HomoloGene: 24986; GeneCards: MRGPRX2; OMA:MRGPRX2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.1 Start 19,054,455 bp[1] End 19,060,717 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B4 Start 48,128,367 bp[2] End 48,149,069 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle skin of abdomen skin of leg subcutaneous adipose tissue rectum urinary bladder fundus vagina gastric mucosa smooth muscle tissue Top expressed in muscle of thigh zone of skin quadriceps femoris muscle lip esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function neuropeptide binding signal transducer activity mast cell secretagogue receptor activity G protein-coupled receptor activity Cellular component plasma membrane membrane integral component of membrane mast cell granule integral component of plasma membrane Biological process sleep positive regulation of cytokinesis mast cell activation G protein-coupled receptor signaling pathway signal transduction sensory perception of pain mast cell degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117194 243978 Ensembl ENSG00000183695 ENSMUSG00000074109 UniProt Q96LB1 Q3UG50 RefSeq (mRNA) NM_001303615 NM_054030 NM_001034868 RefSeq (protein) NP_001290544 NP_473371 NP_001030040 Location (UCSC) Chr 11: 19.05 – 19.06 Mb Chr 7: 48.13 – 48.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Activation of MRGPRX2 on mast cells leads to IgE-independent type 1 hypersensitivity-like symptoms, also known as pseudoallergic reactions, although more rapid and brief. Medications identified to cause MRGPRX2 activation including neuromuscular blocking agents (NMBA) (except for succinylcholine), antibiotics like DNA gyrase inhibitor fluoroquinolones or cell wall synthesis inhibitor vancomycin (which caused Red Man syndrome^[8]), icatibant, leuprolide, and morphine.^[7]

See also

• MAS1 oncogene
• Pseudoallergy