SEPX1

Methionine-R-sulfoxide reductase B1 is an enzyme that in humans is encoded by the SEPX1 gene.^[5][6]

MSRB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MAO
Identifiers
Aliases	MSRB1, SELR, SELX, SEPX1, SepR, HSPC270, methionine sulfoxide reductase B1, SELENOX, SELENOR
External IDs	OMIM: 606216; MGI: 1351642; HomoloGene: 8455; GeneCards: MSRB1; OMA:MSRB1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 1,938,229 bp[1] End 1,943,199 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 12.53 cM Start 24,955,616 bp[2] End 24,961,752 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood right lobe of liver body of pancreas trabecular bone thoracic diaphragm monocyte granulocyte bone marrow periodontal fiber human kidney Top expressed in granulocyte left lobe of liver parotid gland sternocleidomastoid muscle temporal muscle triceps brachii muscle tibiofemoral joint interventricular septum stroma of bone marrow digastric muscle More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor oxidoreductase activity actin binding zinc ion binding metal ion binding methionine-R-sulfoxide reductase activity peptide-methionine (R)-S-oxide reductase activity L-methionine-(R)-S-oxide reductase activity protein binding Cellular component cytoplasm cytosol cytoskeleton nucleus actin cytoskeleton cellular component Biological process immune system process actin filament polymerization innate immune response response to oxidative stress protein repair Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51734 27361 Ensembl ENSG00000198736 ENSMUSG00000075705 UniProt Q9NZV6 Q9JLC3 RefSeq (mRNA) NM_016332 NM_001382264 NM_001382265 NM_013759 NM_001346668 RefSeq (protein) NP_057416 NP_001369193 NP_001369194 NP_001333597 NP_038787 Location (UCSC) Chr 16: 1.94 – 1.94 Mb Chr 17: 24.96 – 24.96 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase B (MsrB) family, and it is expressed in a variety of adult and fetal tissues.^[6]

See also

• MSRA (gene)
• MSRB2
• Methionine oxidation