MSRB2

Methionine-R-sulfoxide reductase B2, mitochondrial is an enzyme that in humans is encoded by the MSRB2 gene.^[5][6][7] The MRSB2 enzyme catalyzes the reduction of methionine sulfoxide to methionine.

MSRB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L1U
Identifiers
Aliases	MSRB2, CBS-1, CBS1, MSRB, PILB, CGI-131, methionine sulfoxide reductase B2
External IDs	OMIM: 613782; MGI: 1923717; HomoloGene: 56555; GeneCards: MSRB2; OMA:MSRB2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p12.2 Start 23,095,579 bp[1] End 23,122,013 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 19,376,251 bp[2] End 19,399,787 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle apex of heart vena cava left ventricle right auricle of heart Skeletal muscle tissue of rectus abdominis muscle of arm biceps brachii triceps brachii muscle Skeletal muscle tissue of biceps brachii Top expressed in interventricular septum myocardium of ventricle right kidney cardiac muscles granulocyte right ventricle lumbar spinal ganglion proximal tubule cervix skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor oxidoreductase activity actin binding zinc ion binding metal ion binding peptide-methionine (R)-S-oxide reductase activity L-methionine-(R)-S-oxide reductase activity Cellular component cytosol mitochondrion Biological process actin filament polymerization response to oxidative stress protein repair regulation of transcription, DNA-templated cellular response to oxidative stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22921 76467 Ensembl ENSG00000148450 ENSMUSG00000023094 UniProt Q9Y3D2 Q78J03 RefSeq (mRNA) NM_012228 NM_029619 RefSeq (protein) NP_036360 NP_083895 Location (UCSC) Chr 10: 23.1 – 23.12 Mb Chr 2: 19.38 – 19.4 Mb PubMed search [3] [4]
Wikidata
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See also

• MSRA (gene)
• Methionine oxidation
• SEPX1