MTCH2

Mitochondrial carrier homolog 2 also known as MTCH2 is a protein which in humans is encoded by the MTCH2 gene.^[5][6][7][8]

MTCH2
Identifiers
Aliases	MTCH2, MIMP, SLC25A50, HSPC032, mitochondrial carrier 2
External IDs	OMIM: 613221; MGI: 1929260; HomoloGene: 8645; GeneCards: MTCH2; OMA:MTCH2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2 Start 47,617,315 bp[1] End 47,642,607 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E1 Start 90,677,499 bp[2] End 90,697,154 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis mucosa of transverse colon rectum right lobe of liver duodenum stromal cell of endometrium islet of Langerhans gastrocnemius muscle human kidney Top expressed in spermatid spermatocyte testicle duodenum jejunum colon right kidney proximal tubule ileum white adipose tissue More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 23788 56428 Ensembl ENSG00000109919 ENSG00000285121 ENSMUSG00000027282 UniProt Q9Y6C9 Q791V5 RefSeq (mRNA) NM_014342 NM_001317231 NM_001317232 NM_001317233 NM_019758 NM_001317241 NM_001317242 NM_001317243 NM_001317244 RefSeq (protein) NP_001304160 NP_001304161 NP_001304162 NP_055157 NP_001304170 NP_001304171 NP_001304172 NP_001304173 NP_062732 Location (UCSC) Chr 11: 47.62 – 47.64 Mb Chr 2: 90.68 – 90.7 Mb PubMed search [3] [4]
Wikidata
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MTCH2 resides on the outer mitochondrial membrane where it co-localizes with the apoptotic Bcl-2 family protein BID.^[9]

Clinical significance

MTCH2 assists in the recruitment of BID into the mitochondria during apoptosis.^[9]

Variants of the MTCH2 gene may be associated with obesity.^[10] MTCH2 represses mitochondrial metabolism such that a deficiency of MTCH2 increases energy consumption and production by mitochondria.^[9]

See also

• Mitochondrial carrier