MTCP1

Protein p13 MTCP-1 is a protein that in humans is encoded by the MTCP1 gene.^[5][6][7][8]

MTCP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A1X, 1QTT, 1QTU
Identifiers
Aliases	MTCP1, P13p8mature T-cell proliferation 1, mature T cell proliferation 1, TCL1C
External IDs	OMIM: 300116; MGI: 102699; HomoloGene: 82921; GeneCards: MTCP1; OMA:MTCP1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 155,064,034 bp[1] End 155,147,937 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A7.3 Start 74,454,050 bp[2] End 74,460,194 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle body of pancreas right testis right adrenal gland left testis left adrenal cortex right adrenal cortex left ovary right ovary gastric mucosa Top expressed in saccule otic placode otic vesicle Rostral migratory stream right kidney neural layer of retina ventricular zone tail of embryo embryo embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase binding protein serine/threonine kinase activator activity Cellular component protein-containing complex Biological process cell population proliferation positive regulation of peptidyl-serine phosphorylation positive regulation of protein serine/threonine kinase activity positive regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4515 17763 Ensembl ENSG00000214827 ENSMUSG00000031200 UniProt P56278 Q61908 Q60945 RefSeq (mRNA) NM_014221 NM_001018025 NM_001039373 RefSeq (protein) NP_001018025 NP_001281206 NP_034969 NP_001034462 Location (UCSC) Chr X: 155.06 – 155.15 Mb Chr X: 74.45 – 74.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. The gene has two ORFs that encode two different proteins. The upstream ORF encodes a 13kDa protein that is a member of the TCL1 family; this protein may be involved in leukemogenesis. The downstream ORF encodes an 8kDa protein that localizes to mitochondria. Alternative splicing results in multiple transcript variants.^[8]

Interactions

MTCP1 has been shown to interact with AKT1.^[9][10]