MTFMT

Mitochondrial methionyl-tRNA formyltransferase is a protein that in humans is encoded by the MTFMT gene.^[5]

MTFMT
Identifiers
Aliases	MTFMT, COXPD15, FMT1, mitochondrial methionyl-tRNA formyltransferase, MC1DN27
External IDs	OMIM: 611766; MGI: 1916856; HomoloGene: 12320; GeneCards: MTFMT; OMA:MTFMT - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.31 Start 65,001,512 bp[1] End 65,029,639 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 C Start 65,343,064 bp[2] End 65,360,336 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle buccal mucosa cell cardiac muscle tissue of right atrium gastrocnemius muscle mucosa of transverse colon gonad tibial arteries right auricle of heart stromal cell of endometrium muscle of thigh Top expressed in medullary collecting duct proximal tubule renal corpuscle right kidney secondary oocyte primary oocyte yolk sac spermatocyte ventricular zone gastrula More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity hydroxymethyl-, formyl- and related transferase activity catalytic activity methionyl-tRNA formyltransferase activity Cellular component mitochondrion Biological process conversion of methionyl-tRNA to N-formyl-methionyl-tRNA biosynthesis protein biosynthesis translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 123263 69606 Ensembl ENSG00000103707 ENSMUSG00000059183 UniProt Q96DP5 Q9D799 RefSeq (mRNA) NM_139242 NM_027134 RefSeq (protein) NP_640335 NP_081410 Location (UCSC) Chr 15: 65 – 65.03 Mb Chr 9: 65.34 – 65.36 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA.^[5] Recessive-type mutations in MTFMT have been shown to cause mitochondrial disease.^[6]