MTMR9

Myotubularin-related protein 9 is a protein that in humans is encoded by the MTMR9 gene.^[5][6][7][8]

MTMR9
Identifiers
Aliases	MTMR9, C8orf9, LIP-STYX, MTMR8, myotubularin related protein 9
External IDs	OMIM: 606260; MGI: 2442842; HomoloGene: 9148; GeneCards: MTMR9; OMA:MTMR9 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p23.1 Start 11,284,816 bp[1] End 11,328,146 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D1 Start 63,757,100 bp[2] End 63,781,431 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 46 pars compacta Region I of hippocampus proper cerebellar vermis pons secondary oocyte pars reticulata Brodmann area 23 middle temporal gyrus Top expressed in seminiferous tubule vestibular membrane of cochlear duct ganglionic eminence superior cervical ganglion superior frontal gyrus barrel cortex dentate gyrus of hippocampal formation granule cell ciliary body retinal pigment epithelium ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding enzyme regulator activity phosphatidylinositol-3-phosphatase activity phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity protein phosphatase binding Cellular component cytosol cytoplasm protein-containing complex endoplasmic reticulum plasma membrane membrane ruffle membrane cell projection perinuclear region of cytoplasm Biological process phosphatidylinositol biosynthetic process dephosphorylation negative regulation of autophagy positive regulation of phosphatase activity protein stabilization regulation of phosphatidylinositol dephosphorylation endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 66036 210376 Ensembl ENSG00000104643 ENSG00000285032 ENSMUSG00000035078 UniProt Q96QG7 Q9Z2D0 RefSeq (mRNA) NM_015458 NM_177594 RefSeq (protein) NP_056273 NP_808262 Location (UCSC) Chr 8: 11.28 – 11.33 Mb Chr 14: 63.76 – 63.78 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate.^[8]

Interactions

MTMR9 has been shown to interact with MTMR6.^[7]