MTSS1

Metastasis suppressor protein 1 is a protein that in humans is encoded by the MTSS1 gene.^[5][6][7] True to its name, it codes for a metastasis suppressor.

MTSS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D1K
Identifiers
Aliases	MTSS1, MIM, MIMA, MIMB, metastasis suppressor 1, I-BAR domain containing, MTSS I-BAR domain containing 1
External IDs	OMIM: 608486; MGI: 2384818; HomoloGene: 8841; GeneCards: MTSS1; OMA:MTSS1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.13 Start 124,550,784 bp[1] End 124,728,473 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D1 Start 58,813,083 bp[2] End 58,953,854 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium glomerulus metanephric glomerulus hair follicle subthalamic nucleus renal medulla skin of hip inferior ganglion of vagus nerve skin of thigh bronchial epithelial cell Top expressed in lobe of cerebellum cerebellar vermis Rostral migratory stream vestibular membrane of cochlear duct stroma of bone marrow zygote habenula secondary oocyte pineal gland iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin monomer binding protein binding identical protein binding actin binding signaling receptor binding Cellular component cytoplasm ruffle endocytic vesicle actin cytoskeleton cytoskeleton Biological process renal tubule morphogenesis nephron tubule epithelial cell differentiation transmembrane receptor protein tyrosine kinase signaling pathway cellular response to fluid shear stress cell adhesion epithelial cell proliferation involved in renal tubule morphogenesis microspike assembly negative regulation of epithelial cell proliferation plasma membrane organization actin cytoskeleton organization glomerulus morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9788 211401 Ensembl ENSG00000170873 ENSMUSG00000022353 UniProt O43312 Q8R1S4 RefSeq (mRNA) NM_001282971 NM_001282974 NM_014751 NM_001363294 NM_001363295 NM_001363296 NM_001363297 NM_001363298 NM_001363299 NM_001363300 NM_001363301 NM_001363302 NM_001146180 NM_144800 RefSeq (protein) NP_001269900 NP_001269903 NP_055566 NP_001350223 NP_001350224 NP_001350225 NP_001350226 NP_001350227 NP_001350228 NP_001350229 NP_001350230 NP_001350231 NP_001139652 NP_659049 NP_001390427 NP_001390428 NP_001390429 NP_001390430 NP_001390431 NP_001390432 NP_001390433 NP_001390434 NP_001390435 NP_001390436 Location (UCSC) Chr 8: 124.55 – 124.73 Mb Chr 15: 58.81 – 58.95 Mb PubMed search [3] [4]
Wikidata
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